Single high dose of the hallucinogen psilocybin, active ingredient of “magic mushrooms,” was enough to cause a measureable personality change lasting at least a year in nearly 60% of the 51 participants, according to a new study.

Personality was measured on a scientifically validated personality scale, which psychologists consider constituents of personality: openness, extroversion, agreeableness, neuroticism, conscientiousness.

Lasting change was found only in “openness,” which includes traits related to imagination, aesthetics, feelings, abstract ideas and general broad-mindedness.

Researchers will now explore possibilities of using psilocybin for helping cancer patients handle the depression and long-time cigarette smokers to overcome their addiction.